dPattern: transcription factor binding site (TFBS) discovery in human genome using a discriminative pattern analysis
نویسندگان
چکیده
MOTIVATION Transcription factor binding sites (TFBSs) are typically short in length, thus search with a profile model from known TFBSs produces many false positives. When combined with additional information, gene expression data in this article, sensitivity and specificity of TFBS search can be improved significantly. RESULTS By modifying our previous REFINEMENT approach, we developed dPattern that searches for occurrences of TFBSs in the promotor regions of up/down regulated or random genes.
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عنوان ژورنال:
- Bioinformatics
دوره 23 19 شماره
صفحات -
تاریخ انتشار 2007